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At a time of great social upheaval, this album and its 1969 follow-up, "Johnny Cash at San Quentin," showed Cash to be a performer of great compassion, humor, and charisma

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Seeking to explain these findings, the researchers posited that the impact of cannabis use on the endocannabinoid system may reinforce the use of alcohol and tobacco through mechanisms related to psychological reward. They added that bidirectionality must be considered, given that the use of one substance may influence the effect of an additional substanceit may enhance a high, for example

[DOI] [PMC free article] [PubMed] [Google Scholar] 177.Baig SA, Giovenco DP